标题:Botulinum Toxin A Injection Using Esophageal Balloon Radiography Combined with CT Guidance for the Treatment of Cricopharyngeal Dysphagia
作者:Huai, Juan; Hou, Ying; Guan, Jiawen; Zhang, Yang; Wang, Yonghui; Zhang, Xiuying; Zhang, Yanyan; Yue, Shouwei
作者机构:[Huai, Juan; Zhang, Yang; Wang, Yonghui; Zhang, Xiuying; Zhang, Yanyan; Yue, Shouwei] Shandong Univ, Dept Phys Med & Rehabil, Qilu Hosp, Jinan, Shando 更多
通讯作者:Yue, SW
通讯作者地址:[Yue, SW]Shandong Univ, Dept Phys Med & Rehabil, Qilu Hosp, Jinan, Shandong, Peoples R China.
来源:DYSPHAGIA
DOI:10.1007/s00455-019-10070-5
关键词:Botulinum toxin A; Deglutition; Deglutition disorders; Dysphagia; CT; guidance; Cricopharyngeal muscle
摘要:Cricopharyngeal dysfunction, especially cricopharyngeal achalasia, is a common cause of dysphagia, while patients with brainstem stroke and medullary damage have a relatively high risk of cricopharyngeal achalasia. The aim of this article was to introduce an improved method of CT-guided method of injecting botulinum toxin A into the cricopharyngeus muscle using esophageal balloon radiography, and to assess the effect of the botulinum toxin A injection on swallowing performance. Seventeen patients with cricopharyngeal dysphagia were treated with botulinum toxin A injection using esophageal balloon radiography combined with CT guidance to the cricopharyngeal muscle. Primary outcome measures, including Functional Oral Intake Scale and Deglutition Handicap Index, were performed at baseline, 1 week, and 1 month after treatment. The Levene method was used to test the homogeneity of variance, and the Kruskal-Wallis test was used to compare the scores between the timepoints. Botulinum toxin A injection resulted in obvious improvement in 15 patients (88.2%) and no improvement in two patients (11.8%). Compared with the scores prior to treatment, the Functional Oral Intake Scale and Deglutition Handicap Index scores were significantly improved at 1 week (P < 0.001 and P = 0.008, respectively) and 1 month after the treatment (P = 0.001 and P < 0.001, respectively). Thus, CT-guided percutaneous injection of botulinum toxin A is probably a relatively safe, well-tolerated, and viable technique for the treatment of cricopharyngeal dysphagia caused by brainstem injury. Localization with a balloon radiography made the needle guidance easier to visualize.
收录类别:SCIE
资源类型:期刊论文
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