标题：Effects of flour bleaching agent on mice liver antioxidant status and ATPases
作者：Xiaojing Jia;Yangxinwei Wu;Ping Liu
作者机构：[Jia, X] Department of Sanitary Inspection and School of Public Health, Shangdong University, 44 Western Wenhua Road, Jinan 250012, China;[ Wu, Y] Mar 更多
通讯作者地址：[Liu, P]Shangdong Univ, Sch Publ Hlth, Dept Sanit Inspect, 44 Western Wenhua Rd, Jinan 250012, Peoples R China.
来源：Environmental toxicology and pharmacology
关键词：Benzoyl peroxide (BPO); Antioxidant status; ATPases; Liver
摘要：Benzoyl peroxide (BPO) is a strong oxidizing agent and widely used as flour bleaching agent. However their potential risk of liver damage is unknown. The aim of this study was to investigate the effects of BPO on mice liver antioxidant status and ATPases according to the actual amount of BPO in flour from Jinan, China. The results showed that the maximum concentration of BPO reached up to 284.6 mg/kg and content of BPO mainly ranged from 0 to 240 mg/kg. Therefore, four groups of mice were gavaged daily with BPO at doses of 0, 50, 100, 200 mg/kg b.w./d for 42 days, respectively. In liver tissue, superoxide dismutase (SOD) activity was significantly decreased, while the content of malondialdehyde (MDA) significantly increased following BPO exposure at 200 mg/kg b.w. BPO significantly decreased the Mg~(2+) -ATPase and Ca~(2+)-ATPase activities of the liver at 200 mg/kg b.w. BPO, at all of the doses assayed, produced non-significant effects on glutathione peroxidase (GSH-Px) and Na~+K~+-ATPase activities.