标题：Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer
作者：Yang, Yongmei; Qu, Ailin; Liu, Jingkang; Wang, Rui; Liu, Yingjie; Li, Gang; Duan, Weili; Fang, Qian; Jiang, Xiumei; Wang, Lili; Zh 更多 作者机构：[Yang, Yongmei; Qu, Ailin; Liu, Jingkang; Wang, Rui; Liu, Yingjie; Duan, Weili; Fang, Qian; Jiang, Xiumei; Wang, Lili; Zheng, Guixi; Du, Lutao; Zhang, 更多
通讯作者地址：[Wang, CX]Shandong Univ, Dept Clin Lab, Qilu Hosp, Jinan 250100, Shandong, Peoples R China.
摘要：MiR-210 is the master hypoxamir that generally exhibits oncogenic properties in most human solid tumors including bladder cancer (BC). However, it remains unknown about the clinical significance of circulating miR-210 levels in BC. In this study, we found that serum miR-210 was up-regulated in patients with BC, and serum levels of miR-210 increased with advancing stage and grade. Moreover, serum miR-210 expression was found to be significantly reduced in paired post-operative samples and elevated in most patients with relapsed BC. Taken together, our data suggest that serum miR-210 could be a potential noninvasive biomarker for screening, predicting and monitoring BC.