标题:Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer
作者:Yang, Yongmei; Qu, Ailin; Liu, Jingkang; Wang, Rui; Liu, Yingjie; Li, Gang; Duan, Weili; Fang, Qian; Jiang, Xiumei; Wang, Lili; Zh 更多
作者机构:[Yang, Yongmei; Qu, Ailin; Liu, Jingkang; Wang, Rui; Liu, Yingjie; Duan, Weili; Fang, Qian; Jiang, Xiumei; Wang, Lili; Zheng, Guixi; Du, Lutao; Zhang, 更多
通讯作者:Wang, CX
通讯作者地址:[Wang, CX]Shandong Univ, Dept Clin Lab, Qilu Hosp, Jinan 250100, Shandong, Peoples R China.
来源:PLOS ONE
出版年:2015
卷:10
期:8
DOI:10.1371/journal.pone.0135168
摘要:MiR-210 is the master hypoxamir that generally exhibits oncogenic properties in most human solid tumors including bladder cancer (BC). However, it remains unknown about the clinical significance of circulating miR-210 levels in BC. In this study, we found that serum miR-210 was up-regulated in patients with BC, and serum levels of miR-210 increased with advancing stage and grade. Moreover, serum miR-210 expression was found to be significantly reduced in paired post-operative samples and elevated in most patients with relapsed BC. Taken together, our data suggest that serum miR-210 could be a potential noninvasive biomarker for screening, predicting and monitoring BC.
收录类别:SCOPUS;SCIE
WOS核心被引频次:15
Scopus被引频次:16
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941992158&doi=10.1371%2fjournal.pone.0135168&partnerID=40&md5=5578a1dfb6d1a955561929ec09edd40b
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