标题：Synthesis and characterization of tannic acid-PEG hydrogel via Mitsunobu polymerization
作者：Chen, Chen; Geng, Xi-wen; Pan, Ya-hui; Ma, Yu-ning; Ma, Yu-xia; Gao, Shu-zhong; Huang, Xiao-jun
作者机构：[Chen, Chen; Pan, Ya-hui; Ma, Yu-ning; Ma, Yu-xia; Gao, Shu-zhong] Shandong Univ Tradit Chinese Med, Dept Acupuncture Moxibust & Tuina, New Mat Res In 更多
通讯作者：Ma, YuNing;Ma, YN;Ma, YX
通讯作者地址：[Ma, YN; Ma, YX]Shandong Univ Tradit Chinese Med, Dept Acupuncture Moxibust & Tuina, New Mat Res Inst, Key Lab, Jinan 250355, Peoples R China.
摘要：Tannic acid (TA) based materials have received significant interest owing to their broad spectrum of chemical and biological properties. Herein, a novel tannic acid based hydrogel, TA-PEG hydrogel, was synthesized via Mitsunobu polymerization/polycondensation, in which TA and polyethylene glycol (PEG) were simply crosslinked together by ether linkages. This method was performed in one pot, straightforward, metal free and robust, ignoring the strong ionic/hydrophobic interactions between tannic acid and PEG. Bearing catechol and pyrogallol units from TA, TA-PEG hydrogel did not only reduce the silver and gold precursor, but also served as a capping agent and stabilizer for the in situ formed Au and Ag nanoparticles (NPs). Furthermore, the antioxidant activity of the hydrogel was excellent (94%) in the case of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging. TA-PEG hydrogel also showed antibacterial activity against Staphylococcus aureus and Escherichia coli. This work suggested a new method leading to polyphenol based soft materials rather than a complex coacervated microstructure. The resulting TA-PEG hydrogel has potential application in biomedical materials.