标题：miR-1204 targets VDR to promotes epithelial-mesenchymal transition and metastasis in breast cancer
作者：Liu, Xiaoyan; Bi, Lei; Wang, Qin; Wen, Mingxin; Li, Ce; Ren, Yidan; Jiao, Qinlian; Mao, Jian-Hua; Wang, Chuanxin; Wei, Guangwei; W 更多 作者机构：[Liu, Xiaoyan; Wen, Mingxin; Wei, Guangwei; Wang, Yunshan] Shandong Univ, Sch Med, Minist Educ, Dept Human Anat, 44 Wenhua Xi Rd, Jinan 250012, Shando 更多
通讯作者：Wei, GW;Wang, YS;Wei, GW;Wang, YS;Wang, YS;Wang, YS
通讯作者地址：[Wei, GW; Wang, YS]Shandong Univ, Sch Med, Minist Educ, Dept Human Anat, 44 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China;[Wei, GW; Wang, YS]S 更多
摘要：Plasmacytoma variant translocation 1 (PVT1) is an lncRNA that plays vital roles in breast cancer (BC) pathogenesis. Increasing evidence suggests that miRNAs that reside in the PVT1 locus are the main driver of the oncogenic roles of PVT1 in cancer. However, the oncogenic role and underlying mechanism of miR-1204, located in the PVT1 locus, in human cancer is still unclear. In this study, we discovered that increased expression of miR-1204 is associated with poor prognosis in BC. Moreover, miR-1204 promotes proliferation, epithelial-mesenchymal transition and invasion of BC cells both in vitro and in vivo. Mechanistic investigations demonstrated that VDR is a novel target gene of miR-1204. Interference of VDR restored miR-1204-mediated BC cell proliferation, tumorigenesis, and metastasis. Collectively, our results demonstrated that the miR-1204-VDR pathway exerts oncogenic effects in BC with potential therapeutic applications in blocking BC development and progression.