标题:Investigation of microemulsion system for transdermal delivery of matrine
作者:Wei, Hong; Fu, Zheng; Mou, Jie; Guo, Ruichen
通讯作者:Wei, H
作者机构:[Wei, Hong; Fu, Zheng; Mou, Jie] Shandong Med Coll, Erhuannan Rd 5460, Jinan 250002, Peoples R China.; [Guo, Ruichen] Shandong Univ, Sch Pharmaceut 更多
会议名称:International Conference on Advanced Engineering Materials and Technology (AEMT2011)
会议日期:JUL 29-31, 2011
来源:MATERIALS AND DESIGN, PTS 1-3
出版年:2011
卷:284-286
页码:219-225
DOI:10.4028/www.scientific.net/AMR.284-286.219
关键词:Matrine; Microemulsion; Transdermal; Simplex lattice
摘要:A new O/W microemulsion system for transdermal matrine delivery was developed in order to provide clinical medication of matrine with a more convenient,reasonable and effective new form.Various factors were investigated including solubility of matrine,the skin permeability of matrine in various components, and the compatibility among surfactants, cosurfactants and oils, aiming to choose suitable surfactants, cosurfactants and oils.The pseudo-ternary phase diagrams were constructed to determine the concentration ratio of components in the microemulsion. The formulation of microemulsion was optimized by using the simplex lattice method.The optimum formulation with the highest skin permeation rate (1239.56 mu g /cm(2)/h) consisted of 7.2% matrine,4.5% ethyl oleate-ethyl butyrate(4:1), 23 % EL-OP(1 :1),15 % PEG-400 and water.
收录类别:CPCI-S;EI;SCOPUS
资源类型:会议论文;期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-79960800480&doi=10.4028%2fwww.scientific.net%2fAMR.284-286.219&partnerID=40&md5=0b23bb4a2fbd31b88e249da4a87abdb7
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