标题:Gremlin-1 Concentrations Are Correlated with the Severity of Knee Osteoarthritis
作者:Yi, Jun; Jin, Qunhua; Zhang, Bin; Wu, Xinqiu; Ge, Dawei
作者机构:[Yi, Jun; Jin, Qunhua] Shandong Univ, Coll Med, Jinan, Shandong, Peoples R China.; [Yi, Jun; Zhang, Bin; Wu, Xinqiu; Ge, Dawei] Shuyang Tradit Chine 更多
通讯作者:Jin, QH;Jin, QH
通讯作者地址:[Jin, QH]Shandong Univ, Coll Med, Jinan, Shandong, Peoples R China;[Jin, QH]Ningxia Med Univ, Gen Hosp, Dept Orthopaed, Ningxia, Peoples R China.
来源:MEDICAL SCIENCE MONITOR
出版年:2016
卷:22
页码:4062-4065
DOI:10.12659/MSM.897849
关键词:Bone Morphogenetic Proteins; Injury Severity Score; Osteoarthritis, Knee
摘要:Background: Gremlin-1, a bone morphogenetic protein (BMP) antagonist, is up-regulated in osteoarthritis (OA). Therefore, we aim to evaluate the correlation between gremlin-1 concentrations and the onset and severity of OA.; Material/Methods: We performed this cross-sectional study in a population of 212 patients with knee OA and 125 healthy controls.; Results: Patients with knee OA had higher serum gremlin-1 concentrations than healthy controls. Serum and synovial fluid (SF) gremlin-1 concentrations increased according to advanced Kellgren-Lawrence grading stages.; Conclusions: Serum and SF gremlin-1 concentrations are correlated with the onset and severity of knee OA.
收录类别:SCOPUS;SCIE
WOS核心被引频次:4
Scopus被引频次:4
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994651534&doi=10.12659%2fMSM.897849&partnerID=40&md5=f026488d55c5f0e3964d8e3e97f1d0a5
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