标题:Shell modulation by tailoring substituents in chitosan for LbL-assembled microcapsules
作者:Zhang, R.;Li, W.;M?hwald, H.;Sui, W.;Wang, Z.;Gao, C.
作者机构:Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, Shandong University, Jinan 250100, China;Key Lab
来源:Journal of Colloid and Interface Science
出版年:2012
页码:40-44
关键词:AFM;Layer-by-layer (LbL);Microcapsules;Modulation;Polysaccharides
摘要:By AFM we report the successful modulation of shell structure (morphology and shell thickness) of microcapsules through tailoring molecular substituents of chitosan. The shell thickness of hollow (HPCS/SA) n (n=5, 7, 9) capsules is more than 3 times that of the (QACS/SA) n (n=5, 7, 9) capsules, due to less charges carried by the neutral -NH _2 substituent group and the induced coily conformation in HPCS, while more charges carried by the positively charged -N(CH3)3+ substituent and the induced extended conformation in QACS (HPCS: hydroxyl propyl chitosan; QACS: quaternary ammonium chitosan; SA: sodium alginate). The ultrathin shells of microcapsules assembled in this work by the layer-by-layer (LbL) self-assembly technique rather than the traditional method of mixing CS, SA and CaCl _2 enable the thickness modulation characterization by AFM on the atomic scale. These microcapsules with tunable shell thickness provide important guidance for potential drug delivery and sustained release.
资源类型:期刊论文
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