标题:Discovery of 17-aroylamido-17-demethoxygeldanamycins as potent antitumor agents
作者:Zhenyu Li;Lejiao Jia;Yuemao Shen;
作者机构:[Zhenyu Li;Lejiao Jia;Yuemao Shen]Key Laboratory of Chemical Biology (Ministry of Education),School of Pharmaceutical Sciences,Shandong University
会议名称:2014年中国药学大会暨中国药师周
来源:2014年中国药学大会暨第十四届中国药师周论文集
出版年:2014
关键词:Heat shock protein 90(Hsp90);antitumor activity;hepatotoxicity;geldanamycin;17-aroylamido-17-demethoxygeldanamycins
摘要:Geldanamycin(GA),a benzoquinone ansamycin,was reported as the first heat shock protein 90(Hsp90)inhibitor.GA binds to the N-terminal domain ATP binding site of Hsp90,inhibiting the chaperone activity of the protein and resulting in disruption of the Hsp90-client protein complexes.This process subseq...
资源类型:会议论文
原文链接:http://kns.cnki.net/kns/detail/detail.aspx?FileName=YYWS201410003173&DbName=CPFD2015
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