标题:Topical application of 0.5% timolol maleate hydrogel for the treatment of superficial infantile hemangioma
作者: Wu, Hai Wei; Liu, Chao; Wang, Xuan; Zhang, Ling; Yuan, Weien; Zheng, Jia Wei; Su, Li Xin; Fan, Xin Dong
作者机构:[Wu, H.W] Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School 更多
通讯作者:Yuan, W(yuanweien@126.com)
通讯作者地址:[Yuan, W] School of Pharmacy, Shanghai Jiao Tong UniversityChina;
来源:Frontiers in Oncology
出版年:2017
卷:7
期:JUN
DOI:10.3389/fonc.2017.00137
关键词:Drug safety; Hydrogel; Infantile hemangioma; Timolol maleate; Topical therapy
摘要:The therapeutic options for infantile hemangiomas (IHs) have been greatly altered since the introduction of oral propranolol for successful treatments of IHs. Recently, there is an increase in the application of topical timolol maleate for treating superficial IHs. In the present study, we developed a new formulation of timolol maleate 0.5% hydrogel and treated 321 patients with superficial IHs to evaluate its efficacy and safety in the treatment of superficial IHs. This new timolol hydrogel was applied three times daily with a mean duration of 7.1 months. Response to treatment was assessed according to cosmetic improvement by using visual analog scale (VAS). The average VAS improvement after treatment was 76.4, with 126 patients (39.3%) achieving excellent responses, 159 patients (49.5%) achieving good responses, 33 patients (10.3%) achieving fair responses, and three patients (0.9%) achieving poor responses. Age at treatment initiation (P = 0.0349) and lesion thickness (P = 0.0147) were significantly associated with therapeutic efficacy. No severe side effects were observed in all patients. In conclusion, this new topical timolol maleate 0.5% hydrogel appears to be a proper candidate for treating superficial IHs, and our study provides supportive evidence and experience of topical timolol maleate in treating superficial IHs. © 2017 Wu, Liu, Wang, Zhang, Yuan, Zheng, Su and Fan.
收录类别:SCOPUS;SCOPUS;
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85024088326&doi=10.3389%2ffonc.2017.00137&partnerID=40&md5=21c5350e1a904055c6f4cd20febfbd61
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