标题：Culture-Positive Spontaneous Ascitic Infection in Patients with Acute Decompensated Cirrhosis: Multidrug-Resistant Pathogens and Antibiotic Strategies
作者：Liu, Jing; Gao, Yanhang; Wang, Xianbo; Qian, Zhiping; Chen, Jinjun; Huang, Yan; Meng, Zhongji; Lu, Xiaobo; Deng, Guohong; Liu, Feng; 更多 作者机构：[Liu, Jing; Zheng, Xin] Huazhong Univ Sci & Technol, Inst Infect & Immunol, Dept Infect Dis, Union Hosp,Tongji Med Coll, Wuhan 430022, Hubei, Peoples 更多
通讯作者地址：[Zheng, X]Huazhong Univ Sci & Technol, Inst Infect & Immunol, Dept Infect Dis, Union Hosp,Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China.
来源：YONSEI MEDICAL JOURNAL
关键词：Spontaneous ascitic infection; cirrhosis; muhidrug-resistant; antibiotic; strategies; risk factors
摘要：Purpose: This study investigated multidrug-resistant (MDR) pathogens and antibiotic strategies of cuhure-positive spontaneous ascitic infection (SAI) in patients with acute decompensated cirrhosis.; Materials and Methods: We retrospectively analyzed 432 acute decompensated cirrhotic patients with culture-positive SAI from 11 teaching hospitals in China (January 2012 to May 2018). A Cox proportional hazards model analysis was conducted to identify independent predictors of 28-day mortality.; Results: A total of 455 strains were isolated from 432 ascitic culture samples. Gram-negative bacteria (GNB), gram-positive bacteria (GPB), and fungi caused 52.3, 45.5, and 2.2% of all SAI episodes, respectively. Episodes were classified as nosocomial (41.2%), healthcare-related (34.7%), and community-acquired (24.1%). Escherichia coli (13.4%) and Klebsiella pneumoniae (2.4%) were extended-spectrum beta-lactamase producing isolates. The prevalence of methicillin-resistant Staphylococcus aureus was 1.1%. Ceftazidime, cefepime, aztreonam, and amikacin were recommended as first-line antibiotics agents for non-MDR GNB infections; piperacillin/tazohactam and carbapenems for MDR GNB in community-acquired and healthcare-related or nosocomial infections, respectively; and vancomycin or linezolid for GPB infections, regardless of drug-resistance status. Multivariate analysis revealed days of hospital stay before SAI, upper gastrointestinal bleeding, white blood cell count, alanine aminotransferase, serum creatinine concentration, total bilirubin, and international normalized ratio as key independent predictors of 28-day mortality.; Conclusion: MDR pathogens and antibiotic strategies were identified in patients with acute decompensated cirrhosis with culture-positive SAI, which may help optimize therapy and improve clinical outcomes.