标题:Comprehensive assessment of the association of ERCC2 Lys751Gln polymorphism with susceptibility to cutaneous melanoma.
作者:Yuhao Dong;Le Zhuang;Weiyuan Ma
作者机构:[Dong, Y] Shandong University School of Medicine, Jinan 250012, China;[ Zhuang, L] Department of Dermatology, Qilu Hospital, Shandong University, Jina 更多
通讯作者:Ma, WY
通讯作者地址:[Ma, WY]Shandong Univ, Qilu Hosp, Dept Dermatol, Jinan 250012, Peoples R China.
来源:Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine
出版年:2013
卷:34
期:2
页码:1155-1160
DOI:10.1007/s13277-013-0657-7
关键词:ERCC2; Polymorphism; Cutaneous melanoma; Meta-analysis
摘要:Previous studies evaluating the association between excision repair cross-complimentary group 2 (ERCC2) Lys751Gln polymorphism and susceptibility to cutaneous melanoma reported conflicting findings. We searched PubMed and Wangfang Medical databases up to October 16, 2012 to identify eligible studies. A total of 8 case-control studies including 3,492 cases and 5,381 controls were included in the meta-analysis. Statistical analysis was performed with Review Manage version 5.1. Odds ratios (ORs) with 95?% confidence intervals (95?%CIs) were used to assess the strength of the association. There was no obvious between-study heterogeneity among those eight studies under all four comparison models. Overall, there was a significant association between ERCC2 Lys751Gln polymorphism and susceptibility to cutaneous melanoma under three genetic models (for Gln versus Lys: OR?=?1.08, 95?% CI?=?1.01-1.15, P?=?0.02; for GlnGln versus LysLys: OR?=?1.16, 95?% CI?=?1.01-1.33, P?=?0.03; for GlnGln/LysGln versus LysLys: OR?=?1.10, 95?% CI?=?1.01-1.21, P?=?0.04). Sensitivity analysis by omitting one study a time showed the significance of the pooled ORs was stable under all those three genetic models above. Therefore, the meta-analysis suggests that there is a significant association between ERCC2 Lys751Gln polymorphism and susceptibility to cutaneous melanoma.
收录类别:SCOPUS;SCIE
WOS核心被引频次:8
Scopus被引频次:7
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877155820&doi=10.1007%2fs13277-013-0657-7&partnerID=40&md5=6f8cbc0774a996f1ac4e8d6f8b8df956
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