标题:Modulation of paraventricular firing rate by secretin in vivo
作者:Chen, Xin-Yi; Wang, Hua; Xue, Yan; Chen, Lei
作者机构:[Chen, Xin-Yi] Shandong Univ, Sch Med, Dept Physiol, Jinan 250012, Peoples R China.; [Chen, Lei] Qingdao Univ, Dept Physiol, Fac Med, Qingdao 266071 更多
通讯作者:Chen, L
通讯作者地址:[Chen, L]Qingdao Univ, Dept Physiol, Fac Med, Qingdao 266071, Shandong, Peoples R China.
来源:NEUROSCIENCE LETTERS
出版年:2013
卷:532
页码:29-32
DOI:10.1016/j.neulet.2012.10.055
关键词:Paraventricular nucleus; Secretin; Single unit recordings
摘要:The paraventricular nucleus (PVN) of hypothalamus is a major integrative center in homeostatic control. Morphological studies have revealed a high level of secretin and secretin receptor expression in the PVN. To investigate the direct electrophysiological effects of secretin in the PVN, in vivo extracellular recordings were performed in the present study. In 24 out of the 46 paraventricular neurons, micro-pressure ejection of secretin increased the firing rate from 3.07 +/- 0.43 Hz to 4.86 +/- 0.70 Hz. In another 8 out of the 46 paraventricular neurons, secretin decreased the firing rate from 2.61 +/- 0.46 Hz to 1.41 +/- 0.25 Hz. In the remaining 14 paraventricular neurons, secretin did not alter the firing rate significantly. The present findings provided direct electrophysiological evidence for the possible functions of secretin in the PVN. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
收录类别:SCOPUS;SCIE
WOS核心被引频次:1
Scopus被引频次:1
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84871080099&doi=10.1016%2fj.neulet.2012.10.055&partnerID=40&md5=816ac5834bc444191289c2f228532827
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