标题:Nrdp1 inhibits metastasis of colorectal cancer cells by EGFR signaling-dependent MMP7 modulation
作者:Jiang, Yongsheng;Sun, Shaochuan;Liu, Guoqin;Yan, Bing;Niu, Jun
作者机构:[Jiang, Y] Department of General Surgery, Jinan Central Hospital, Shandong University, Jinan, 250013, China;[ Sun, S] Department of General Surgery, J 更多
通讯作者:Niu, J
通讯作者地址:[Niu, J]Shandong Univ, Qilu Hosp, Dept Gen Surg, 107 West Wenhua Rd, Jinan 250012, Peoples R China.
来源:Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine
出版年:2015
卷:36
期:2
页码:1129-1133
DOI:10.1007/s13277-014-2726-y
关键词:Neuregulin receptor degradation protein-1 (Nrdp1);Epidermal growth factor (EGF);Colorectal cancer;MMP7
摘要:The molecular mechanism underlying cancer invasiveness and metastasis of colorectal cancer (CRC) remains elusive. Here we reported a strong correlation of the levels of neuregulin receptor degradation protein-1 (Nrdp1) and matrix metalloproteinase-7 (MMP7) in CRC from the patients. We then used a human CRC line, Caco-2, to study the underlying molecular basis. We found that Nrdp1 inhibited the phosphorylation of ErB3, a key player in epidermal growth factor receptor (EGFR) signaling in Caco-2 cells, which is required for activation of MMP7 to promote cell invasion. Our findings thus reveal Nrdp1, EGFR signaling, and MMP7 as promising therapeutic targets for preventing the metastasis of CRC.
收录类别:SCOPUS;SCIE
WOS核心被引频次:11
Scopus被引频次:10
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925515934&doi=10.1007%2fs13277-014-2726-y&partnerID=40&md5=dff4eb3e0bf0a60465825be922d7db1b
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