标题：Proposed revision of N categories to the 8th edition of the AJCC-TNM staging system for non-surgical esophageal squamous cell cancer
作者：Hu, Kai; Kang, Ning; Liu, Yang; Guo, Dong; Jing, Wang; Lu, Jiamei; Tan, Tianmeng; Lv, Caitiao; Deng, Yuyan; Long, Jianxiong; Wang, 更多 作者机构：[Hu, Kai; Yu, Jinming] Shandong Univ, Sch Med, Jinan, Shandong, Peoples R China.; [Hu, Kai; Kang, Ning; Lu, Jiamei; Wang, Rensheng] Guangxi Med Univ 更多
通讯作者：Wang, RS;Yu, JM
通讯作者地址：[Wang, RS]Guangxi Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, Nanning, Guangxi, Peoples R China;[Yu, JM]Shandong Univ, Shandong Canc Hosp, Dept Ra 更多
关键词：AJCC-TNM staging system; esophageal squamous cell cancer; N category;; non-surgical; prognosis
摘要：The 8th edition of the American Joint Committee on Cancer Tumor-Node-Metastasis (AJCC-TNM) staging system for esophageal cancer (EC) retained the definition of N categories based on the number of metastatic lymph nodes (LN). However, it is difficult to accurately determine the number of metastatic LN without surgery. This study aimed to propose a revision to the N categories of the 8th edition AJCC-TNM staging system that makes staging easier to perform and better represents the prognosis of non-surgical esophageal squamous cell cancer (ESCC). We retrospectively reviewed the data of 336 patients with ESCC. The revised N categories were based on the anatomic regions of LN metastasis (cervix, thorax and abdomen). Survival was analyzed using the Kaplan-Meier method and compared using the log-rank test. Multivariate analyses were performed using the Cox proportional hazard model. Survival differences were adequately discriminated when the revised N categories were used. Subgroup analyses by T stage showed significant difference in overall survival between the revised N categories. Multivariate analyses demonstrated that T stage, revised N category, age, sex and treatment modality were independent risk factors, with the revised N category being the most significant variable. The revised N categories determined in this study can be used to fill gaps in the staging system for patients with non-surgical ESCC, which can help clinicians to make better treatment decisions and more effectively predict patient prognoses. Future large-scale studies are required to validate these results.