标题:Association between vitamin d receptor polymorphisms and periodontitis: A meta-analysis
作者:Chen,L.-L.;Li,H.;Zhang,P.-P.;Wang,S.-M.
作者机构:[Chen, L.-L] School of Public Health, Shandong University, 44 Wen-hua - xi-lu, Jinan 250012, China;[ Li, H] Department of Haematology, Qilu Hospital, 更多
通讯作者:Wang, SM
通讯作者地址:[Wang, SM]Shandong Univ, Sch Publ Hlth, 44 Wen Hua Xi Lu, Jinan 250012, Peoples R China.
来源:Journal of Periodontology
出版年:2012
卷:83
期:9
页码:1095-1103
DOI:10.1902/jop.2011.110518
关键词:Calcitriol;Genetic;Meta-analysis;Periodontitis;Polymorphism;Receptors
摘要:Background: The purpose of the meta-analysis is to explore the association between vitamin D receptor polymorphisms (including four gene loci: Taq-I, Bsm-I, Apa-I, and Fok-I) for susceptibility to periodontitis (either chronic [CP] or aggressive [AP]). Up to now, there has been only one systematic review focusing on this topic. We obtained some different findings compared with the previously published literature. Methods: Nineteen case-control studies were identified through a search of multiple electronic databases (from January 1, 1999 to June 30, 2011). The pooled odds ratios (ORs) and 95% confidence intervals (CIs) using codominant, dominant, and recessive genetic models from meta-analysis were the main outcome measure. The Harbord test was used to detect the publication bias for each group. Results: Eighteen identified articles met the eligibility criteria. Through overall analyses, no statistical association was found between polymorphisms of the four gene loci and periodontitis. However, based on subgroup analyses, a significant association between the Taq-I variants and CP rather than AP was shown in Asians (OR = 0.590; 95% CI = 0.425, 0.818) but not in whites (OR = 0.823; 95% CI = 0.637, 1.063). No statistically significant association was found between polymorphisms of Bsm-I and Apa-I with either AP or CP. The Fok-I polymorphism showed a statistical association with AP (OR = 1.583; 95% CI = 1.157, 2.166) instead of CP (OR = 1.081; 95% CI = 0.638, 1.830) in Asians. Conclusions: The results of the present meta-analysis indicate the following: 1) the mutant allele t of the Taq-I locus may be a protective factor for CP but not for AP in Asians, although this was not true in whites; 2) the mutant allele F of the Fok-I locus appeared to be a risk factor for AP rather than CP in Asians; and 3) Bsm-I and Apa-I polymorphisms were found to have no significant associations with susceptibility to periodontitis (CP/AP).
收录类别:SCOPUS;SCIE
WOS核心被引频次:19
Scopus被引频次:24
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865991413&doi=10.1902%2fjop.2011.110518&partnerID=40&md5=e0d63a998260e3162e37bca6cc5eb705
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