标题：Influence of hemodynamics on recanalization of totally occluded intracranial aneurysms: a patient-specific computational fluid dynamic simulation study Laboratory investigation
作者：Li, Chuanhui; Wang, Shengzhang; Chen, Jialiang; Yu, Hongyu; Zhang, Ying; Jiang, Fan; Mu, Shiqing; Li, Haiyun; Yang, Xinjian
作者机构：[Li, Chuanhui; Zhang, Ying; Mu, Shiqing; Yang, Xinjian] Capital Med Univ, Beijing Neurosurg Inst, Beijing Tiantan Hosp, Beijing 100050, Peoples R Chin 更多
通讯作者地址：[Yang, XJ]Capital Med Univ, Beijing Neurosurg Inst, Beijing Tiantan Hosp, Tiantan Xili 6, Beijing 100050, Peoples R China.
来源：JOURNAL OF NEUROSURGERY
关键词：intracranial aneurysm; hemodynamics; total embolization; recanalization;; wall shear stress; vascular disorders
摘要：Object. Some totally occluded intracranial aneurysms may recur. The role of hemodynamic mechanisms in this process remains to be elucidated. The authors used computational fluid dynamic analysis and investigated the local hemodynamic characteristics at the aneurysm neck before and after total embolization, attempting to identify hemodynamic risk factors leading to recurrence of totally embolized aneurysms.; Methods. Between May 2008 and June 2010, the authors recruited 17 consecutive patients with totally occluded intracranial aneurysms (7 recanalized and 10 stable lesions). Using patient-specific 3D digital subtraction angiography data, the hemodynamic features before and after embolization were retrospectively characterized.; Results. The overall preembolization blood flow patterns were nearly the same in the recanalized and stable groups, with no significant difference in either the maximum wall shear stress (WSS) (p = 0.914) or the spatially averaged WSS (p = 0.322) at peak systole at the aneurysm neck. After occlusion, the overall flow pattern changed, and the WSS distribution at the treated aneurysm neck differed in the 2 groups. In all of the 7 recanalized cases, both the maximum WSS and spatially averaged WSS at peak systole at the treated aneurysm neck were higher than those at the aneurysm neck before embolization. In contrast, both parameters were decreased in 70%-80% of the stable cases. After embolization, both the maximum WSS (p = 0.021) and spatially averaged WSS (p = 0.041) at peak systole at the treated aneurysm neck were higher in the recanalized group than in the stable group.; Conclusions. Higher WSS at the treated aneurysm neck after total embolization can be an important hemodynamic factor that contributes to aneurysm recurrence after endovascular treatment. (http://thejns.org/doi/abs/10.3171/2012.5.JNS111558)