标题:Cage the firefly luciferin! - a strategy for developing bioluminescent probes
作者:Jing Li;Laizhong Chen;Lupei Du
作者机构:[Li, J] Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, Shandong 250012, China;[ Chen, L] Department of Medicinal C 更多
通讯作者:Li, MY
通讯作者地址:[Li, MY]Shandong Univ, Sch Pharm, Dept Med Chem, Key Lab Chem Biol Nat Prod,MOE, Jinan 250012, Shandong, Peoples R China.
来源:Chemical Society Reviews
出版年:2013
卷:42
期:2
页码:662-676
DOI:10.1039/c2cs35249d
摘要:Bioluminescent imaging (BLI) has been widely applicable in the imaging of process envisioned in life sciences. As the most conventional technique for BLI, the firefly luciferin-luciferase system is exceptionally functional in vitro and in vivo. The state-of-the-art strategy in such a system is to cage the luciferin, in which free luciferin is conjugated with distinctive functional groups, thus accommodating an impressive toolkit for exploring various biological processes, such as monitoring enzymes activity, detecting bioaetive small molecules, evaluating the properties of molecular transporters, etc. This review article summarizes the rational design of caged luciferins towards diverse biotargets, as well as their applications in bioluminescent imaging. It should be emphasized that these caged luciferins can stretch out the applications of bioluminescence imaging and shed light upon understanding the pathogenesis of various diseases.
收录类别:SCOPUS;SCIE
WOS核心被引频次:74
Scopus被引频次:77
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84871982117&doi=10.1039%2fc2cs35249d&partnerID=40&md5=32d762bb0c9a5210e6a175fde0c39f2e
TOP