标题:Reduced IL-33 plasma levels in aplastic anemia
作者:Sun, Ming; Ma, Hai-Feng; Che, Ye-Yun; Cui, Xin
作者机构:[Sun, Ming; Ma, Hai-Feng; Che, Ye-Yun] Linzi Dist Peoples Hosp, Dept Hematol, Zibo 255400, Peoples R China.; [Cui, Xin] Shandong Univ, Shandong Prov 更多
通讯作者:Cui, X
通讯作者地址:[Cui, X]Shandong Univ, Shandong Prov Hosp, Dept Internal Med, Jinan 250021, Peoples R China.
来源:CANCER CELL INTERNATIONAL
出版年:2015
卷:15
DOI:10.1186/s12935-015-0270-5
关键词:Aplastic anemia; Interleukin 33; Interleukin 17; sST2; Cytokines
摘要:Background: In this study, we aim to evaluate the balance of interleukin (IL)-33 and its soluble receptor sST2 in patients with aplastic anemia (AA).; Methods: Plasma IL-33, IL-17 and sST2 levels were measured in patients with active AA (n = 31), AA in remission (n = 29) and in healthy subjects (n = 30), using enzyme linked immunosorbent assays (ELISAs).; Results: The results showed that sST2 and IL-17 levels were significantly elevated in patients with active AA when compared to control subjects, but IL-33 levels were significantly lower in AA patients, which resulted in elevated sST2/IL-33 ratios in patients with active disease. During remission stages, the levels of these cytokines were comparable to those of healthy controls.; Conclusions: The elevated levels of sST2/IL-33 in the plasma during active stages of the disease suggest a possible role in the pathogenesis and course of AA.
收录类别:SCOPUS;SCIE
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84949747663&doi=10.1186%2fs12935-015-0270-5&partnerID=40&md5=4d7bcf40869ce0236135462d69af5ad5
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