标题：Reduced IL-33 plasma levels in aplastic anemia
作者：Sun, Ming; Ma, Hai-Feng; Che, Ye-Yun; Cui, Xin
作者机构：[Sun, Ming; Ma, Hai-Feng; Che, Ye-Yun] Linzi Dist Peoples Hosp, Dept Hematol, Zibo 255400, Peoples R China.; [Cui, Xin] Shandong Univ, Shandong Prov 更多
通讯作者地址：[Cui, X]Shandong Univ, Shandong Prov Hosp, Dept Internal Med, Jinan 250021, Peoples R China.
来源：CANCER CELL INTERNATIONAL
关键词：Aplastic anemia; Interleukin 33; Interleukin 17; sST2; Cytokines
摘要：Background: In this study, we aim to evaluate the balance of interleukin (IL)-33 and its soluble receptor sST2 in patients with aplastic anemia (AA).; Methods: Plasma IL-33, IL-17 and sST2 levels were measured in patients with active AA (n = 31), AA in remission (n = 29) and in healthy subjects (n = 30), using enzyme linked immunosorbent assays (ELISAs).; Results: The results showed that sST2 and IL-17 levels were significantly elevated in patients with active AA when compared to control subjects, but IL-33 levels were significantly lower in AA patients, which resulted in elevated sST2/IL-33 ratios in patients with active disease. During remission stages, the levels of these cytokines were comparable to those of healthy controls.; Conclusions: The elevated levels of sST2/IL-33 in the plasma during active stages of the disease suggest a possible role in the pathogenesis and course of AA.