标题：A new flavonol C-glycoside and a rare bioactive lignanamide from Piper wallichii Miq. Hand.-Mazz
作者：WANG Pei-Pei;ZHAO Guo-Wei;XIA Wen;HAN En-Ji;XIANG Lan
作者机构：[Wang, P.-P] School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China;[ Zhao, G.-W] School of Pharmaceutical Sciences, Shandong Uni 更多
通讯作者地址：[Lan, X]Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Peoples R China.
关键词：Piper wallichii;Flavonol C-glycoside;Lignanamide;DPPH scavenging activity;AChE inhibitory activity
摘要：This study was conducted to investigate the chemical constituents of Piper wallichii (Miq.) Hand.-Mazz. and evaluate their biological activity. Compounds were isolated by various column chromatographic methods, and their structures were elucidated on the basis of physical characteristics and spectral data. The 1, 1-dipheny1-2-picrylhydrazyl (DPPH)-scavenging activity and acetylcholinesterase (AChE)-inhibitory activity of the compounds were evaluated. Five compounds were obtained and identified as 8-C-beta-D-glucopyranosylkaempferol-3-0-beta-D-glucopyranoside (1), 1, 2-dihydro-6,8-dimethoxy-7-hydroxy-1-(3, 5-dimethoxy-4-hydroxypheny1)-N-1, N-2-bis42-(4-hydroxyphenypethy1]-2, 3-naphthalene dicarboxamide (2), goniothalactam (3), aristololactam A IIIa (4) and piperlonguminine (5). Compound 1 was a new flavonol C-glycoside, 2 was a rare lignanamide, which was isolated from the family Piperaceae for the first time, and compound 3 was isolated from this plant for the first time. Among them, 2 showed potent DPPH-scavenging activity, with 1050 of 31.38 +/- 0.97 mu mol.L-1; Compounds 2, 3, and 4 showed AChE inhibitory activity at 100 umol.L-1, with inhibition rates of 28.57% +/- 1.47%, 18.48% +/- 2.41% and 17.4% +/- 3.03%, respectively.