标题:A new flavonol C-glycoside and a rare bioactive lignanamide from Piper wallichii Miq. Hand.-Mazz
作者:WANG Pei-Pei;ZHAO Guo-Wei;XIA Wen;HAN En-Ji;XIANG Lan
作者机构:[Wang, P.-P] School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China;[ Zhao, G.-W] School of Pharmaceutical Sciences, Shandong Uni 更多
通讯作者:Xiang, L(xianglan02@sdu.edu.cn)
通讯作者地址:[Lan, X]Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Peoples R China.
来源:中国天然药物(英文版)
出版年:2014
卷:12
期:5
页码:377-381
DOI:10.3724/SP.J.1009.2014.00377
关键词:Piper wallichii;Flavonol C-glycoside;Lignanamide;DPPH scavenging activity;AChE inhibitory activity
摘要:This study was conducted to investigate the chemical constituents of Piper wallichii (Miq.) Hand.-Mazz. and evaluate their biological activity. Compounds were isolated by various column chromatographic methods, and their structures were elucidated on the basis of physical characteristics and spectral data. The 1, 1-dipheny1-2-picrylhydrazyl (DPPH)-scavenging activity and acetylcholinesterase (AChE)-inhibitory activity of the compounds were evaluated. Five compounds were obtained and identified as 8-C-beta-D-glucopyranosylkaempferol-3-0-beta-D-glucopyranoside (1), 1, 2-dihydro-6,8-dimethoxy-7-hydroxy-1-(3, 5-dimethoxy-4-hydroxypheny1)-N-1, N-2-bis42-(4-hydroxyphenypethy1]-2, 3-naphthalene dicarboxamide (2), goniothalactam (3), aristololactam A IIIa (4) and piperlonguminine (5). Compound 1 was a new flavonol C-glycoside, 2 was a rare lignanamide, which was isolated from the family Piperaceae for the first time, and compound 3 was isolated from this plant for the first time. Among them, 2 showed potent DPPH-scavenging activity, with 1050 of 31.38 +/- 0.97 mu mol.L-1; Compounds 2, 3, and 4 showed AChE inhibitory activity at 100 umol.L-1, with inhibition rates of 28.57% +/- 1.47%, 18.48% +/- 2.41% and 17.4% +/- 3.03%, respectively.
收录类别:CSCD;SCOPUS;SCIE
WOS核心被引频次:4
Scopus被引频次:4
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901373808&doi=10.1016%2fS1875-5364%2814%2960047-9&partnerID=40&md5=d545cdec4b8f9028fb03f15e0e2dd02c
TOP