标题:Nanoadduct relieves: Alleviation of developmental toxicity of Cr(VI) due to its spontaneous adsorption to Mg(OH)2nanoflakes
作者:Wang, Zhiping ;Li, Chunhui ;Mu, Yan ;Lin, Zhang ;Yi, Anji ;Zhang, Qiu ;Yan, Bing
作者机构:[Wang, Zhiping ;Li, Chunhui ;Yi, Anji ] School of Public Health, Shandong University, Jinan, China;[Lin, Zhang ] State Key Lab of Structural Chemistry 更多
通讯作者:Zhang, Qiu
来源:Journal of Hazardous Materials
出版年:2015
卷:287
页码:296-305
DOI:10.1016/j.jhazmat.2015.02.005
摘要:During pregnancy, both the mother and fetus are vulnerable to environmental pollution by particulate matters and chemicals. Although the toxicity of free pollutants has been frequently reported, the impact of nanoparticle/pollutant adducts on the vulnerable pregnant population remains unclear. In this study, pregnant mice were orally exposed to Mg(OH)2nanoflakes and nanoflakes adsorbed with Cr(VI) anions during the peri-implantation and organogenesis stages of pregnancy at doses that did not induce systemic toxicity or pregnancy complications. The nano-Mg(OH)2/Cr(VI) adducts formation reduced fetal developmental toxicity compared with the toxicity induced by the same concentration of free Cr(VI) anions.
© 2015 Elsevier B.V.
收录类别:EI
资源类型:期刊论文
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