标题:Expression of dendritic cell lysosome-associated membrane protein and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin in condyloma acuminatum lesions
作者:Ma,W.-Y.;Zhuang,L.;Qi,Q.-C.;Sun,Q.
通讯作者:Sun, Q
作者机构:[Ma, W.-Y] Department of Dermatology, Qilu Hospital, Shandong University, Jinan, Shandong Province, China;[ Zhuang, L] Department of Dermatology, Qilu 更多
会议名称:2nd Eastern Asia Dermatology Congress
会议日期:JUN 13-15, 2012
来源:The Journal of international medical research
出版年:2013
卷:41
期:1
页码:138-145
DOI:10.1177/0300060513476991
关键词:Condyloma acuminatum;Dendritic cell lysosome-associated membrane protein (DC-LAMP);Dendritic cell-specific intercellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN);Dendritic cells
摘要:Objective: Retrospective, observational study to explore the role of dendritic cells (DCs) in condyloma acuminatum lesions (genital warts) and their relationship with duration of the disease. Methods: Condyloma acuminatum lesion samples were collected from male patients with the condition and compared with normal foreskin samples from male volunteers. Cellular locations of dendritic cell lysosome-associated membrane protein (DC-LAMP) and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) were detected using immunohistochemistry. Levels of both proteins were determined using Western blot analysis; levels of their corresponding mRNAs were measured using reverse transcription-polymerase chain reaction. Results: The mRNA and protein levels of DC-LAMP and DC-SIGN were both significantly higher in condyloma acuminatum lesions (n = 30 samples) compared with normal skin samples (n = 13). Levels of DC-LAMP and DC-SIGN protein and duration of disease were inversely correlated. Conclusions: DC-LAMP and DC-SIGN may be involved in the pathogenesis of condyloma acuminatum. Their levels were inversely correlated with the duration of disease, suggesting that DCs might be involved in human papillomavirus clearance.
收录类别:CPCI-S;SCOPUS;SCIE
资源类型:会议论文;期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878414624&doi=10.1177%2f0300060513476991&partnerID=40&md5=30994dc91998319df64125f51126c3e3
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