标题：Oxytocin inhibits ovarian cancer metastasis by repressing the expression of MMP-2 and VEGF
作者：Ji, Haoyi; Liu, Na; Yin, Yingchun; Wang, Xinmei; Chen, Xiaoyang; Li, Jing; Li, Jingxin
作者机构：[Ji, Haoyi; Chen, Xiaoyang] Shandong Univ, Sch Med, Dept Med Eth, Jinan 250012, Shandong, Peoples R China.; [Liu, Na] Shandong Univ, Qilu Hosp, Dept 更多
通讯作者：Li, J;Li, JX
通讯作者地址：[Li, J]Cent Hosp Zibo, Dept Pathol, Zibo 255036, Peoples R China;[Li, JX]Shandong Univ, Sch Med, Dept Physiol, Jinan 250012, Shandong, Peoples R China 更多
来源：JOURNAL OF CANCER
关键词：Oxytocin; ovarian cancer; metastasis; MMP-2; VEGF
摘要：Breastfeeding is associated with a decreased risk of ovarian cancer. However, the mechanism underlying this apparent clinical benefit is unknown. Oxytocin (OXT), a hypothalamic nonapetide, plays a crucial role in many reproductive and behavioural functions. In recent year, OXT acts as a growth regulator in many kind of tumor tissues, through the activation of a specific G-coupled transmembrane receptor, the oxytocin receptor (OXTR). OXT has been proved to inhibit the proliferation, migration and invasion of ovarian cancer SKOV3 cells in vitro. But, the underlying mechanisms remain unknown. Here, we found OXT inhibited proliferation, and critically migration and invasion of human ovarian cancer cells SKOV3 and A2780. Strikingly, OXT inhibited ovarian cancer metastasis by repressing the expressions of MMP-2 and VEGF. Moreover, OXT inhibited vascular endothelial cell tube formation by reducing the VEGF production from ovarian cancer cells. Our findings may provide a possible explanation for breastfeeding-associated protective effects and suggest new therapeutic opportunities for ovarian cancer.