标题：DNA nanostructure-based drug delivery nanosystems in cancer therapy
作者：Wu, Dandan; Wang, Lei; Li, Wei; Xu, Xiaowen; Jiang, Wei
作者机构：[Wu, Dandan; Wang, Lei; Li, Wei; Jiang, Wei] Shandong Univ, Sch Pharm, Minist Educ, Key Lab Nat Prod Chem Biol, Jinan 250012, Shandong, Peoples R Chin 更多
通讯作者：Wang, L;Jiang, W
通讯作者地址：[Wang, L; Jiang, W]Shandong Univ, Sch Pharm, Minist Educ, Key Lab Nat Prod Chem Biol, Jinan 250012, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF PHARMACEUTICS
关键词：DNA nanostructure; Drug delivery; Nanosystems; Cancer therapy
摘要：DNA as a novel biomaterial can be used to fabricate different kinds of DNA nanostructures based on its principle of GC/AT complementary base pairing. Studies have shown that DNA nanostructure is a nice drug carrier to overcome big obstacles existing in cancer therapy such as systemic toxicity and unsatisfied drug efficacy. Thus, different types of DNA nanostructure-based drug delivery nanosystems have been designed in cancer therapy. To improve treating efficacy, they are also developed into more functional drug delivery nanosystems. In recent years, some important progresses have been made. The objective of this review is to make a retrospect and summary about these different kinds of DNA nanostructure-based drug delivery nanosystems and their latest progresses: (1) active targeting; (2) mutidrug co-delivery; (3) construction of stimuli-responsive/intelligent nanosystems.