标题：Anticancer Effects of Constituents of Herbs Targeting Osteosarcoma
作者：Su Qing-hong; Xu Xiao-qun; Wang Jun-fu; Luan Jun-wen; Ren Xia; Huang Hai-yan; Bian Si-shan
作者机构：[Su Qing-hong; Xu Xiao-qun; Wang Jun-fu; Luan Jun-wen; Ren Xia; Huang Hai-yan] Shandong Acad Med Sci, Inst Basic Med, Jinan 250062, Peoples R China.; 更多
通讯作者地址：[Bian, SS]Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Orthopaed, Jinan 250014, Peoples R China.
来源：CHINESE JOURNAL OF INTEGRATIVE MEDICINE
关键词：constituents of herbs; osteosarcoma; metastasis; review
摘要：Osteosarcoma is a rare primary malignancy of bone that is prone to early metastasis. Resection surgery and chemotherapeutic regimens are current standard treatments for osteosarcoma. However, the long-term survival rate of patients with osteosarcoma is low due to a high risk of metastasis. Hence, a new approach is urgently needed to improve the treatment of osteosarcoma. Compared with chemotherapy, natural active constituents isolated from herbs exhibit less adverse effects and better anti-tumor effects. This study aimed to summarize the anticancer effects of constituents of herbs on the progression and metastasis of osteosarcoma cells. It showed that many constituents of herbs inhibited osteosarcoma by targeting proliferation, matrix metalloproteinases, integrin and cadherin, and angiogenesis. The findings might be beneficial for the development of new drugs and treatment strategies.