标题：Olfactory ensheathing cells transplantation attenuates chronic cerebral hypoperfusion induced cognitive dysfunction and brain damages by activating Nrf2/HO-1 signaling pathway
作者：Yu, Ailing; Mao, Leilei; Zhao, Fangfang; Sun, Baoliang
作者机构：[Yu, Ailing; Zhao, Fangfang] Shandong Univ, Taian City Cent Hosp, Dept Neurol, Sch Med, Tai An 271000, Shandong, Peoples R China.; [Mao, Leilei] Tai 更多
通讯作者地址：[Sun, BL]Taishan Med Coll, Affiliated Hosp, Dept Neurol, Key Lab Cerebral Microcirculat Univ Shandong, 2 Yingsheng East Rd, Tai An 271000, Shandong, P 更多
来源：AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
关键词：Chronic cerebral hypoperfusion; OECs transplantation; Nrf2/HO-1 pathway
摘要：Chronic cerebral hypoperfusion (CCH) has become a crucial factor contributing to neurological disorders and cognitive deficits. Olfactory ensheathing cells (OECs) transplantation has been widely used to repair central nerve systems (CNS) injury, however, whether this intervention has therapeutic effects on CCH-induced cognitive dysfunction and brain damages is still unknown. In this study, we sought to determine the potential therapeutic effects of OECs transplantation on CCH. Two days after the establishment of 2VO rat model, OECs or its medium transplantation were performed via intrastriatal injection. In our study, OECs treatment significantly improved learning and memory in 2VO rats. Transplantation of OECs also significantly reduced brain cell death, neuroinflammation and oxidative stress. Mechanistically, transplantation of OECs increased the expression of nuclear factor-like 2 (Nrf2) and hemeoxygenase 1 (HO-1). Finally, treatment with Brusatol, a Nrf2 inhibitor, markedly abolished the neuroprotective effects of OECs on cognitive decline, oxidative stress, Nrf2 and HO-1 expression. These results demonstrated that OECs transplantation protected CCH-induced cognitive impairment and brain injury by suppressing neuroinflammation and oxidative stress. The activation of Nrf2/HO-1 signaling pathway may contribute to the neuroprotection of OECs transplantation in CCH.