标题：Endoplasmic reticulum stress, an important factor in the development of Parkinson's disease
作者：Mou Z.; Yuan Y.-H.; Zhang Z.; Song L.-K.; Chen N.-H.
作者机构：[Mou, Z] State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese A 更多
通讯作者地址：[Chen, N.-H] Department of pharmacology, institute of material medical, Chinese academy of medical sciences and Peking union medical college, 2 Nanwei 更多
关键词：Compound; Endoplasmic reticulum stress; Hormesis; Neuroinflammation; Parkinson's disease
摘要：Similar to other types of neuronal degeneration, Parkinson's disease (PD) is characterized by the aggregation of a pathological protein, α-synuclein. The endoplasmic reticulum (ER) is the principal site of protein synthesis, quality control and degradation. Genetic mutants, environmental insults and other factors disturb ER balance and induce the accumulation of misfolded/unfolded proteins, which initiate ER stress and disturb normal cell function. ER stress perturbs Ca2+ homeostasis and initiates the activation of autophagy and inflammasomes, which have been identified as risk factors for the development of PD. However, the mechanisms by which ER stress contributes to the processed of PD pathogenesis and development remain unclear. This review summarizes current knowledge of ER stress and highlights the principal role of ER stress in PD pathogenesis which may help reveal novel sight to illustrate the pathomechanism of PD. © 2020