标题：The Medicinal Potential of Promising Marine Macrolides with Anticancer Activity
作者：Yunkun Qi;Shutao Ma
作者机构：[Qi, Y] Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Jinan 250012, China;[ Ma, S] 更多
通讯作者地址：[Ma, ST]Shandong Univ, Dept Med Chem, Sch Pharmaceut Sci, 44 W Culture Rd, Jinan 250012, Peoples R China.
关键词：biological activity;cancer;chemical synthesis marine macrolides;mechanism of action
摘要：Marine natural products have become a major source of new chemical entities in the discovery of potential anticancer agents that potently suppress various molecular targets. In particular, the marine macrolides, which include an array of novel biomolecules endowed with outstanding cytotoxic and/or antiproliferative activities, are a prominent class of marine natural products that offer continued promise for breakthroughs in anticancer research. Herein we highlight some recent studies of promising marine macrolides, paying particular attention to their discovery, anticancer activities, mechanisms of action, chemical synthesis, and representative analogues.