标题:Granulocyte-colony stimulating factor promotes proliferation, migration and invasion in glioma cells
作者:Wang,J.;Yao,L.;Zhao,S.;Zhang,X.;Yin,J.;Zhang,Y.;Chen,X.;Gao,M.;Ling,E.-A.;Hao,A.;Li,G.
作者机构:[Wang, J] Department of Neurosurgery, Qi Lu Hospital, Shandong University, China;[ Yao, L] Department of Traditional Chinese Integrated Western Medici 更多
通讯作者:Hao, AJ
通讯作者地址:[Hao, AJ]Shandong Univ, Shandong Prov Key Lab Mental Disorders, Minist Educ Expt Teratol, Dept Histol & Embryol,Key Lab,Sch Med, Jinan 250100, Peoples 更多
来源:Cancer biology & therapy
出版年:2012
卷:13
期:6
页码:389-400
DOI:10.4161/cbt.13.6.19237
关键词:G-CSF;Glioma;Progression;Recurrence2;STAT 3;Tumorigenesis
摘要:Sustaining proliferative signaling is one of the hallmarks of cancer. Granulocyte-colony stimulating factor (G-CSF), a hematopoietic growth factor that controls proliferation and differentiation of neural stem cells, may contribute to the development of glioma. In the present study, we evaluated the expression of G-CSF and its receptor (G-CSFR) in various grades of glioma samples and primary cell culture derived from a glioblastoma patient as well as different human glioma cell lines. We showed that G-CSF and G-CSFR were widely expressed by glioma samples, primary glioma cell culture and glioma cell lines. The expression levels of G-CSF and G-CSFR were not significantly different between different grades of glioma. G-CSF promoted proliferation, migration and invasion of glioma cells. Neutralization of G-CSFR with its antibody inhibited growth and metastasis of glioma cells in vitro. We also showed that activation of signal transducer and activator transcription 3 (STAT 3) as well as expression of several of its downstream effectors was regulated by G-CSF. Taken together, the present results suggest that G-CSF contributes to glioma progression that may be linked to glioma genesis and recurrence.
收录类别:SCOPUS;SCIE
WOS核心被引频次:23
Scopus被引频次:24
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860254573&doi=10.4161%2fcbt.19237&partnerID=40&md5=e7126062a81f80a1c6220d869a0b84bc
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