标题:Cystatin C and asymptomatic coronary artery disease in patients with metabolic syndrome and normal glomerular filtration rate
作者:Xie Qing; Wang Furong; Liu Yunxia; Zhang Jian; Wang Xuping; Gao Ling
作者机构:[Xie Qing; Gao Ling] Shandong Univ, Prov Hosp, Dept Cent Lab, Jinan 250100, Peoples R China.; [Xie Qing] Shandong Univ, Dept Pharm, Qilu Hosp, Jinan 更多
通讯作者:Gao, L
通讯作者地址:[Gao, L]Shandong Univ, Prov Hosp, Dept Cent Lab, Jinan 250100, Peoples R China.
来源:CARDIOVASCULAR DIABETOLOGY
出版年:2012
卷:11
DOI:10.1186/1475-2840-11-108
关键词:Cystatin C; Gensini score; Metabolic syndrome; Asymptomatic coronary; artery disease
摘要:Background: All of the components of Metabolic syndrome (MetS) have been regarded as risk factors for coronary artery disease (CAD). Early detection of CAD in asymptomatic patients with MetS remains a challenge. Cystatin C, which has been proposed as a novel marker of renal dysfunction, is correlated with mortality in CAD, The purpose of the study was to evaluate whether cystatin C is a potential marker of asymptomatic CAD in MetS patients with normal kidney function.; Methods: A total of 211asymptomatic MetS patients without prior history of CAD patients were included in a cross-sectional study. Patients were divided into MetS with asymptomatic CAD (n = 136) and MetS without CAD (n = 75) groups according to coronary angiograph results. Serum cystatin C levels were measured using particle enhanced immunonephelometric assays. We first assessed whether there is an independent association of cystatin C with the presence and severity of asymptomatic CAD. Then, we investigated the association between cystatin C and other biochemical risk factors for atherosclerosis.; Results: Serum cystatin C levels in patients with asymptomatic CAD were significantly higher than those without CAD (P = 0.004). A multiple logistic regression analysis demonstrated cystatin C was independently associated with the presence of asymptomatic CAD (OR = 1.326, 95% CI: 1.086-1.619). On receiver operating characteristics (ROC) analysis, the area under the curve (AUC) was 0.622 (95 % CI: 0543-0.701, P = 0.003), and cystatin C showed a moderate predictive value. Furthermore, cystatin C was independently correlated with Gensini score (standardized beta = 0.183, P = 0.007), and serum cystatin C levels increased with the increasing of number of disease vessels (P = 0.005). In a multiple stepwise regression analysis, uric acid (UA)(P < 0.001), body mass index (BMI)(P = 0.002), triglyceride(TG)(P = 0.03), estimated glomerular filtration rate (eGFR)(P < 0.001), and fibrinogen(P = 0.001) were independently associated with cystatin C.; Conclusions: Serum cystatin C in our study was significantly associated with the presence and severity of asymptomatic CAD in MetS patients with normal kidney function, suggesting that cystatin C is probably more than a marker of glomerular filtration rate.
收录类别:SCOPUS;SCIE
WOS核心被引频次:2
Scopus被引频次:23
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84867651873&doi=10.1186%2f1475-2840-11-108&partnerID=40&md5=98613d4f57866f7245932414f0f12947
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