标题:Ferulic acid alleviates symptoms of preeclampsia in rats by upregulating vascular endothelial growth factor
作者:Gong, Weiyan; Wan, Jipeng; Yuan, Qing; Man, Quanzhan; Zhang, Xiaojing
作者机构:[Gong, Weiyan; Wan, Jipeng; Zhang, Xiaojing] Shandong Univ, Dept Obstet & Gynecol, Shandong Prov Hosp, Jinan, Shandong, Peoples R China.; [Yuan, Qin 更多
通讯作者:Zhang, XJ
通讯作者地址:[Zhang, XJ]Shandong Univ, Maternal & Child Hlth Care Hosp Shandong Prov, Dept Obstet & Gynecol, Shandong Prov Hosp, Jinan, Shandong, Peoples R China.
来源:CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
出版年:2017
卷:44
期:10
页码:1026-1031
DOI:10.1111/1440-1681.12801
关键词:ferulic acid; placenta growth factor; preeclampsia; soluble fms-like; tyrosine kinase-1; vascular endothelial growth factor
摘要:Preeclampsia is a complication affecting pregnant women worldwide, which leads to maternal and fetal morbidity and mortality. In this study, we evaluated the efficacy of ferulic acid (FA) on an N-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced rat model of preeclampsia. L-NAME was administered to pregnant rats to induce preeclampsia. 48 rats were divided into three experimental groups (n=16 each): control group, preeclampsia group and preeclampsia with FA treatment (preeclampsia+FA). Physiological characteristics such as urine volume, total urine protein and blood pressure were assessed. Expressions levels of urinary nephrin and podocin mRNAs were analyzed by RT-PCR. Levels of renal vascular endothelial growth factor (VEGF), renal soluble fms-like tyrosine kinase-1 (sFlt-1) and serum placenta growth factor (PlGF) were also examined. Urine volume, total urine protein and blood pressure were markedly increased in preeclampsia group rats compared to control (P<.05), which were then significantly reduced in preeclampsia+FA group (P<.05). Expressions of urinary nephrin and podocin mRNAs, levels of VEGF, sFlt-1 and PlGF were also reversed in preeclampsia+FA group compared to preeclampsia rats (P<.05). We hereby report for the first time, FA alleviates preeclampsia symptoms in a rat preeclampsia model, supporting its potential value in treating preeclampsia.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028961775&doi=10.1111%2f1440-1681.12801&partnerID=40&md5=df2dba23fdd4eb54247895a73058bd5f
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