标题：Ferulic acid alleviates symptoms of preeclampsia in rats by upregulating vascular endothelial growth factor
作者：Gong, Weiyan; Wan, Jipeng; Yuan, Qing; Man, Quanzhan; Zhang, Xiaojing
作者机构：[Gong, Weiyan; Wan, Jipeng; Zhang, Xiaojing] Shandong Univ, Dept Obstet & Gynecol, Shandong Prov Hosp, Jinan, Shandong, Peoples R China.; [Yuan, Qin 更多
通讯作者地址：[Zhang, XJ]Shandong Univ, Maternal & Child Hlth Care Hosp Shandong Prov, Dept Obstet & Gynecol, Shandong Prov Hosp, Jinan, Shandong, Peoples R China.
来源：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
关键词：ferulic acid; placenta growth factor; preeclampsia; soluble fms-like; tyrosine kinase-1; vascular endothelial growth factor
摘要：Preeclampsia is a complication affecting pregnant women worldwide, which leads to maternal and fetal morbidity and mortality. In this study, we evaluated the efficacy of ferulic acid (FA) on an N-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced rat model of preeclampsia. L-NAME was administered to pregnant rats to induce preeclampsia. 48 rats were divided into three experimental groups (n=16 each): control group, preeclampsia group and preeclampsia with FA treatment (preeclampsia+FA). Physiological characteristics such as urine volume, total urine protein and blood pressure were assessed. Expressions levels of urinary nephrin and podocin mRNAs were analyzed by RT-PCR. Levels of renal vascular endothelial growth factor (VEGF), renal soluble fms-like tyrosine kinase-1 (sFlt-1) and serum placenta growth factor (PlGF) were also examined. Urine volume, total urine protein and blood pressure were markedly increased in preeclampsia group rats compared to control (P<.05), which were then significantly reduced in preeclampsia+FA group (P<.05). Expressions of urinary nephrin and podocin mRNAs, levels of VEGF, sFlt-1 and PlGF were also reversed in preeclampsia+FA group compared to preeclampsia rats (P<.05). We hereby report for the first time, FA alleviates preeclampsia symptoms in a rat preeclampsia model, supporting its potential value in treating preeclampsia.