标题：Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation
作者：Liu, Xin-guang; Liu, Yu; Chen, Feng
作者机构：[Liu, Xin-guang; Chen, Feng] Shandong Univ, Qilu Hosp, Dept Hematol, Jinan, Peoples R China.; [Liu, Yu] Qilu Univ Technol, Sch Chem & Pharmaceut Eng 更多
通讯作者：Chen, F;Chen, F
通讯作者地址：[Chen, F]Shandong Univ, Qilu Hosp, Dept Hematol, Jinan, Peoples R China;[Chen, F]Capital Med Univ, Beijing Shijitan Hosp, Ctr Canc, Beijing Key Lab Th 更多
关键词：soluble fibrinogen-like protein 2; immunoregulation; transplantation;; hepatitis; autoimmunity
摘要：Soluble fibrinogen-like protein 2 (sFGL2) is the soluble form of fibrinogen-like protein 2 belonging to the fibrinogen-related protein superfamily. It is now well characterized that sFGL2 is mainly secreted by regulatory T cell (Treg) populations, and exerts potently immunosuppressive activities. By repressing not only the differentiation and proliferation of T cells but also the maturation of dendritic cells (DCs), sFGL2 acts largely as an immunosuppressant. Moreover, sFGL2 also induces apoptosis of B cells, tubular epithelial cells (TECs), sinusoidal endothelial cells (SECs), and hepatocytes. This mini-review focuses primarily on the recent literature with respect to the signaling mechanism of sFGL2 in immunomodulation, and discusses the clinical implications of sFGL2 in transplantation, hepatitis, autoimmunity, and tumors.