标题：Advances in curcumin-loaded nanopreparations: improving bioavailability and overcoming inherent drawbacks
作者：Zhang, Yanan; Khan, Abdur Rauf; Fu, Manfei; Zhai, Yujia; Ji, Jianbo; Bobrovskaya, Larisa; Zhai, Guangxi
作者机构：[Zhang, Yanan; Khan, Abdur Rauf; Fu, Manfei; Ji, Jianbo; Zhai, Guangxi] Shandong Univ, Coll Pharm, Jinan, Shandong, Peoples R China.; [Zhai, Yujia] 更多
通讯作者地址：[Zhai, GX]Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, 44 WenhuaXilu, Jinan 250012, Shandong, Peoples R China.
来源：JOURNAL OF DRUG TARGETING
关键词：Curcumin; cancer; nanopreparations; bioavailability; liposomes; micelles
摘要：Curcumin (CUR), one of the major extracts of turmeric, has gained extensive attention owing to its extraordinary benefits as anti-cancer, anti-bacterial, anti-ulcerative, anti-depressant, anti-inflammatory and wound healing agent. However, a major barrier in its application lies in its inherent nature of low water solubility, instability, and short half-life. Different strategies have been adopted to overcome these barriers like preparing nano-sized formulations and exploiting stable and hydrophilic derivatives, and collaborative drug delivery. Nanopreparations could maintain the pharmacological effect of drugs, even the holistic effects of drug extracts. In addition, nanopreparations based on novel materials make it a reality to regulate the drug release rate according to the various environmental conditions. The therapeutic applications and novel investigated nanopreparations of CUR for prevention and treatment of various diseases, especially, cancer and inflammatory disorders are discussed in this review.