标题：Luminescent nanoprobes for in-vivo bioimaging
作者：Niu, Jinye; Wang, Xu; Lv, Jianzheng; Li, Yong; Tang, Bo
作者机构：[Niu, Jinye; Wang, Xu; Lv, Jianzheng; Li, Yong; Tang, Bo] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Collaborat Innovat Ctr Functionalized P 更多
通讯作者地址：[Tang, B]Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Collaborat Innovat Ctr Functionalized Probes Chem, Key Lab Mol & Nano Probes,Minist Educ 更多
来源：TRAC-TRENDS IN ANALYTICAL CHEMISTRY
关键词：Carbon-based nanomaterial; Dye-doped nanoparticle; Gold nanocluster;; In-vivo bioimaging; Luminescent nanoprobe; Nanoluminophore; Persistent; luminescence nanoparticle; Porous silicon nanoparticle; Quantum dot;; Upconversion nanophosphor
摘要：Luminescent bioimaging, based on nanoprobes, is highly selective, sensitive, and non-invasive, and it has become a powerful tool for visualizing tissues with cellular or sub-cellular resolution and mapping of molecular events. Taking into account the progressive increase in research on luminescent nanoprobe-based bioimaging, especially in living animals, we review recent advances in this area. Research is classified according to the nanoluminophore into quantum dots, upconversion nanophosphors, dye-doped nanoparticles (NPs), and other luminescent nanoprobes, including gold nanoclusters, carbon-based nanomaterials, persistent luminescence NPs, and porous silicon NPs. We demonstrate the progress and the challenges of applying luminescent nanoprobes from basic to clinical research, which is supposed to benefit the exploitation and the development of high-performance nanoprobes for in-vivo bioimaging. (C) 2014 Elsevier Ltd. All rights reserved.