标题:Identification of Novel Variants of Metadherin in Breast Cancer
作者:Liu, Xianqiang; Zhang, Ning; Li, Xiao; Moran, Meena S.; Yuan, Cunzhong; Yan, Shi; Jiang, Liyu; Ma, Tingting; Haffty, Bruce G.; Yang, 更多
作者机构:[Liu, Xianqiang; Zhang, Ning; Jiang, Liyu; Ma, Tingting; Yang, Qifeng] Shandong Univ, Sch Med, Qilu Hosp, Dept Breast Surg, Jinan 250100, Shandong, Pe 更多
通讯作者:Liu, XQ
通讯作者地址:[Liu, XQ]Shandong Univ, Sch Med, Qilu Hosp, Dept Breast Surg, Jinan 250100, Shandong, Peoples R China.
来源:PLOS ONE
出版年:2011
卷:6
期:3
DOI:10.1371/journal.pone.0017582
摘要:Metadherin (MTDH, also known as AEG-1, and Lyric) has been demonstrated to play a potential role in several significant aspects of tumor progression. It has been reported that overexpression of MTDH is associated with progression of disease and poorer prognosis in breast cancer. However, there are no studies to date assessing variants of the MTDH gene and their potential relationship with breast cancer susceptibility. Thus, we investigated all variants of the MTDH gene and explored the association of the variants with breast cancer development. Our cohort consisted of full-length gene sequencing of 108 breast cancer cases and 100 healthy controls; variants were detected in 11 breast cancer cases and 13 controls. Among the variants detected, 9 novel variants were discovered and 2 were found to be associated with the susceptibility of breast cancer. However, additional studies need to be conducted in larger sample sizes to validate these findings and to further investigate whether these variants are prognostic in breast cancer patients.
收录类别:SCOPUS;SCIE
WOS核心被引频次:25
Scopus被引频次:26
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-79952375168&doi=10.1371%2fjournal.pone.0017582&partnerID=40&md5=deb791d71d30ca0bf2235318df57212e
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