标题：miRNAs in acute myeloid leukemia
作者：Liao, Qiong; Wang, Bingping; Li, Xia; Jiang, Guosheng
作者机构：[Liao, Qiong; Li, Xia; Jiang, Guosheng] Shandong Acad Med Sci, Inst Basic Sci, Key Lab Rare & Uncommon Dis Shandong Prov, Jinan, Shandong, Peoples R C 更多
通讯作者：Li, X;Jiang, GS;Li, X
通讯作者地址：[Li, X; Jiang, GS]Shandong Acad Med Sci, Inst Basic Sci, Key Lab Rare & Uncommon Dis Shandong Prov, Jinan, Shandong, Peoples R China;[Li, X]Shandong U 更多
关键词：miRNAs regulatory signaling pathways; acute myeloid leukemia;; pathogenesis; prognosis; miRNA-directed therapy
摘要：MicroRNAs (miRNAs) are small, non-coding RNAs found throughout the eukaryotes that control the expression of a number of genes involved in commitment and differentiation of hematopoietic stem cells and tumorigenesis. Widespread dysregulation of miRNAs have been found in hematological malignancies, including human acute myeloid leukemia (AML). A comprehensive understanding of the role of miRNAs within the complex regulatory networks that are disrupted in malignant AML cells is a prerequisite for the development of therapeutic strategies employing miRNA modulators. Herein, we review the roles of emerging miRNAs and the miRNAs regulatory networks in AML pathogenesis, prognosis, and miRNA-directed therapies.