标题：Flavonoids from the leaves of Epimedium Koreanum Nakai and their potential cytotoxic activities
作者：Zhang H.; Wu X.; Wang J.; Wang M.; Wang X.; Shen T.; Wang S.; Ren D.
作者机构：[Zhang, H] Department of Natural Product Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shan 更多
通讯作者地址：[Ren, D] Department of Natural Product Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shando 更多
来源：Natural Product Research
关键词：cytotoxicity; Epimedium koreanum Nakai; flavonoids; flavonol glycoside
摘要：Phytochemical studies on the leaves of Epimedium koreanum Nakai have resulted in the discovery of two new flavonol glycosides, koreanoside F (1) and koreanoside G (2), along with six known flavonoids. Their structures were elucidated on the basis of HRESIMS, UV, IR, 1 D NMR and 2 D NMR data. Absolute configurations of 1 and 2 was further determined by 13 C-NMR spectra with gate decoupling (GD). All of the compounds were evaluated for cytotoxic activities by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT) assay. The results indicated that compounds 3, 5, 6, 7 and 8 inhibited the proliferation of A549 and NCI-292 cells with IC 50 values of 5.7–23.5 μM. Real-time monitoring in three kinds of lung cancer cells and a kind of human bronchial epithelial cells treated with compound 6 was also assessed. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.