标题：Licoflavonol is an inhibitor of the type three secretion system of Salmonella enterica serovar Typhimurium
作者：Guo, Zhixing; Li, Xiaoli; Li, Jianfang; Yang, Xuefei; Zhou, Yuan; Lu, Chunhua; Shen, Yuemao
作者机构：[Guo, Zhixing; Li, Jianfang; Zhou, Yuan; Lu, Chunhua; Shen, Yuemao] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, Jinan 250012, S 更多
通讯作者：Lu, CH;Shen, YM
通讯作者地址：[Lu, CH; Shen, YM]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, Jinan 250012, Shandong, Peoples R China.
来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
关键词：Type three secretion system (T3SS); Licoflavonol; Salmonella enterica; serovar Typhimurium
摘要：As an important food-borne human pathogen, Salmonella enterica serovar Typhimurium depends on its type III secretion system (T3SS) as a major virulence factor to cause disease all over the world. The T3SS secretes effector proteins to facilitate invasion into host cells. In this study, twenty prenylated flavonoids (1-20) were screened for their anti-T3SS activity, revealing that several analogs exhibited strong inhibitory effects on the secretion of Salmonella pathogenicity island 1 (SPI-1)-associated effector proteins without affecting the growth of bacteria and the secretion of the flagellar protein FliC. Among the flavonoids 1-20, licoflavonol (20) exhibited a strong inhibitory effect on the secretion of the SPI-1 effector proteins via regulating the transcription of the SicA/InvF genes, and the transportation of the effector protein SipC. In summary, licoflavonol, a novel natural inhibitor of Salmonella T3SS, could be a promising candidate for novel type of anti-virulence drugs. (C) 2016 Elsevier Inc. All rights reserved.