标题：A Ketone Functionalized Gd(III)-MOF with Low Cytotoxicity for Anti-Cancer Drug Delivery and Inhibiting Human Liver Cancer Cells
作者：Sun, Li-Li; Li, Yu-Hong; Shi, Hao
作者机构：[Sun, Li-Li; Shi, Hao] Shandong Univ, Dept Med Imaging, Qianfoshan Hosp, Jinan, Shandong, Peoples R China.; [Sun, Li-Li; Li, Yu-Hong] Jinzhou Med Un 更多
通讯作者地址：[Shi, H]Shandong Univ, Dept Med Imaging, Qianfoshan Hosp, Jinan, Shandong, Peoples R China.
来源：JOURNAL OF CLUSTER SCIENCE
关键词：Metal-organic framework; Porous carrier; One-dimensional channel; Liver; cancer
摘要：In recent years, great attention has been paid to the construction of new porous metal-organic frameworks as effective drug carriers due to their high surface areas, considerable biocompatibility and controlled drug release performance. In this study, a new Gd(III) metal-organic framework with the chemical formula of [Gd(BCB)(DMF)](H2O)(2) has been successfully prepared using 4,4,4-benzenetricarbonyltribenzoic acid (H3BCB) as organic linkers and 1D Gd(III)-based secondary building unit chain as metal nodes. The title complex was characterized by single-crystal X-ray diffraction analysis, elemental analysis, Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis and gas sorption measurements. Complex 1 shows 1D channel of 13.7x6.4 angstrom(2) along the c axis, which is large enough for accommodating anticancer drug 5-Fu (5-Fluorouracil) molecules. The drug loading and release experiments are carried out on the desolvated 1 (1a), which reveals that 1a could uptake 36.4% weight of 5-Fu and release 5-Fu in a pH-dependent manner. Also, the prepare carrier is found to be bio-compatible with HCC cells (liver cancer cells) and oral epidermal cells (normal cells), when tested by MTT assay. In addition, the 5-Fu loaded carrier shows promising anticancer activity against the human liver cancer cells HCC.