标题：The Clinical Application of Raman Spectroscopy for Breast Cancer Detection
作者：Gao, Pin; Han, Bing; Du, Ye; Zhao, Gang; Yu, Zhigang; Xu, Weiqing; Zheng, Chao; Fan, Zhimin
作者机构：[Gao, Pin; Han, Bing; Du, Ye; Zhao, Gang; Fan, Zhimin] Jilin Univ, Hosp 1, Dept Breast Surg, Changchun 130021, Peoples R China.; [Yu, Zhigang; Zheng 更多
通讯作者地址：[Fan, ZM]Jilin Univ, Hosp 1, Dept Breast Surg, Changchun 130021, Peoples R China;[Zheng, C]Shandong Univ, Hosp 2, Dept Breast Surg, Jinan 250033, Peop 更多
来源：JOURNAL OF SPECTROSCOPY
摘要：Raman spectroscopy has been widely used as an important clinical tool for real- time in vivo cancer diagnosis. Raman information can be obtained from whole organisms and tissues, at the cellular level and at the biomolecular level. The aim of this paper is to review the newest developments of Raman spectroscopy in the field of breast cancer diagnosis and treatment. Raman spectroscopy can distinguish malignant tissues from noncancerous/normal tissues and can assess tumor margins or sentinel lymph nodes during an operation. At the cellular level, Raman spectra can be used to monitor the intracellular processes occurring in blood circulation. At the biomolecular level, surface-enhanced Raman spectroscopy techniques may help detect the biomarker on the tumor surface as well as evaluate the efficacy of anticancer drugs. Furthermore, Raman images reveal an inhomogeneous distribution of different compounds, especially proteins, lipids, microcalcifications, and their metabolic products, in cancerous breast tissues. Information about these compounds may further our understanding of the mechanisms of breast cancer.