标题：RETRACTED: Epigenetic aberrant methylation of tumor suppressor genes in small cell lung cancer (Retracted article. See vol. 6, pg. E35, 2014)
作者：Wang, Shuai; Wang, Zhou
作者机构：[Wang, Shuai; Wang, Zhou] Shandong Univ, Prov Hosp, Dept Thorac Surg, Jinan 250021, Peoples R China.
通讯作者地址：[Wang, Z]Shandong Univ, Prov Hosp, Dept Thorac Surg, 324 Jingwu Rd, Jinan 250021, Peoples R China.
来源：JOURNAL OF THORACIC DISEASE
关键词：Small cell lung cancer (SCLC); tumor suppressor gene (TSG); promotor; methylation; hypermethylation
摘要：Small cell lung cancer (SCLC), a special type of lung cancer, is reputed to carry a poor prognosis. The morbidity of SCLC is increasing in China and other countries. A variety of DNA alterations associated with non-small cell lung cancer (NSCLC) have been described. However, genetic and epigenetic changes of SCLC are not well established. Few studies have demonstrated that epigenetic silencing of key tumor suppressor genes (TSGs) is pivotal to initiation and development of SCLC. Recently, promoter methylation of many TSGs have been identified in SCLC. These novel TSGs are potential tumor biomarkers for early diagnosis and prognostic prediction. Moreover, epigenetic promoter methylation of TSGs could be a target of intervention with a wide prospect of clinical application. This review summarizes recent studies on promoter methylation of TSGs in SCLC and aims to provide better understanding of the promoter methylation in tumorigenesis and progression of SCLC.