标题：Recent Advance in Tumor-associated Carbohydrate Antigens (TACAs)-based Antitumor Vaccines
作者：Feng, Danyang; Shaikh, Abdul Sami; Wang, Fengshan
作者机构：[Feng, Danyang; Wang, Fengshan] Shandong Univ, Sch Pharmaceut Sci, Inst Biochem & Biotechnol Drug, Key Lab Chem Biol Nat Prod,Minist Educ, Jinan 25001 更多
通讯作者：Wang, FS;Wang, FS
通讯作者地址：[Wang, FS]Shandong Univ, Sch Pharmaceut Sci, Inst Biochem & Biotechnol Drug, Key Lab Chem Biol Nat Prod,Minist Educ, Jinan 250012, Shandong, Peoples R 更多
来源：ACS CHEMICAL BIOLOGY
关键词：Tumor-associated carbohydrate antigen; Cancer immunotherapy;; Glycoconjugate; MHCI and MHCII; Zwitterionic polysaccharide;; Glycosylation; Metabolic glycoengineering; Self-adjuvanting vaccine
摘要：Cancer cells can be distinguished from normal cells by displaying aberrant levels and types of carbohydrate structures on their surfaces. These carbohydrate structures are known as tumor-associated carbohydrate antigens (TACAs). TACAs were considered as promising targets for the design of anticancer vaccines. Unfortunately, carbohydrates alone can only evoke poor immunogenicity because they are unable to induce T-cell-dependent immune responses, which is critical for cancer therapy. Moreover, immunotolerance and immunosuppression are easily induced by using natural occurring TACAs as antigens due to their endogenous property. This review summarizes the recent strategies to overcome these obstacles: (1) covalently coupling TACAs to proper carriers to improve immunogenicity, including clustered or multivalent conjugate vaccines, (2) coupling TACAs to T-cell peptide epitopes or the built-in adjuvant to form multicomponent glycoconjugate vaccines, and (3) developing vaccines based on chemically modified TACAs, which is combined with metabolic engineering of cancer cells.