标题：Syk is low-expressed in non-small-cell lung cancer and inversely correlates with patient's survival
作者：Peng, Chuanliang; Sun, Qifeng; Hao, Yingtao; Cong, Bo; Zhao, Yunpeng; Zhao, Xiaogang
作者机构：[Peng Chuanliang] Thoracic Department, Second Hospital of Shandong University, Ji'nan, Shandong 250033, China.;[Sun Qifeng] Thoracic Department, Secon 更多
通讯作者地址：[Zhao, XG]Shandong Univ, Hosp 2, Thorac Dept, Jinan 250033, Peoples R China.
来源：ACTA BIOCHIMICA ET BIOPHYSICA SINICA
关键词：Syk; non-small-cell lung cancer
摘要：The protein tyrosine kinases (PTKs) are a group of enzyme proteins that can phosphorylate substrate protein tyrosine residues, and are involved in many signal transduction pathways. They also play an important role in the control of cell differentiation, proliferation, and spreading. A recent study has found that Syk, as a tumor suppressor of PTKs, is closely related to tumor invasion and metastasis . Syk has been also showed to have potential inhibitory effect in breast, gastric, and pancreatic cancers [2-4]. Sung et al.  found that in the mouse mammary gland, loss of one Syk allele profoundly increased proliferation, ductal branching, and invasion of epithelial cells through the mammary fat pad during puberty, and that mammary carcinoma developed after 1 year. An increasing number of clinical studies have revealed a correlation between reduced Syk expression and increased risk of metastasis formation, and Syk is assigned as a potential new prognostic marker in different tumor types . In this study, we examined the expression of Syk in non-small-cell lung cancer (NSCLC) and analyzed its association with the prognosis.