标题：Implanted spike wave electric stimulation promotes survival of the bone marrow mesenchymal stem cells and functional recovery in the spinal cord injured rats.
作者：Wu W;Zhao H;Xie B;Liu H;Chen Y;Jiao G;Wang H
作者机构：[Wu, W] Department of Trauma Surgery, Shandong University Qilu Hospital, Wenhuaxi Road 107, Jinan 250012, China;[ Zhao, H] Department of Trauma Surger 更多
通讯作者地址：[Chen, YZ]Shandong Univ, Qilu Hosp, Dept Trauma Surg, Wenhuaxi Rd 107, Jinan 250012, Peoples R China.
来源：Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences
关键词：Mesenchymal stem cells; Electric field stimulation; Spinal cord injury
摘要：Transplantation of bone marrow-derived mesenchymal stromal cells (BMSCs) into the injured spinal cord may provide therapeutic benefit, but its application is limited by their poor survival and low differentiation rate into neurons. Electrical stimulation (ES) has been reported to promote survival and differentiation of the BMSCs. Therefore we investigated whether implanted spike wave ES could improve survival of BMSCs after transplantation and result in functional improvement in animals with spinal cord injury. Our results showed that the number and ratio of survived BMSCs near the lesion site were significantly increased in the BMSCs+ES-treated group as compared to BMSCs transplantation or ES treatment alone group. Furthermore, results from BBB scales, SSEP and DTI demonstrated a significant improved functional recovery in the BMSCs+ES group. This indicated that implanted spike wave ES could promote the bioactivity of BMSCs and their survival. This represents a new therapeutic potential of the combination of BMSCs transplantation with implanted spike wave ES to treat spinal cord injury.