标题：Fractional Order Dynamics for Clarithromycin Against Helicobacter Pylori
作者：Li, Yan; Sun, Yundong; Wang, Wenchao
作者机构：[Li, Yan; Wang, Wenchao] Shandong Univ, Sch Control Sci & Engn, Jinan 250061, Shandong, Peoples R China.; [Sun, Yundong] Shandong Univ, Sch Med, Jin 更多
会议名称：6th IEEE Data Driven Control and Learning Systems Conference (DDCLS)
会议日期：MAY 26-27, 2017
来源：2017 6TH DATA DRIVEN CONTROL AND LEARNING SYSTEMS (DDCLS)
关键词：Helicobacter pylori; Clarithromycin; Fractional calculus; Equivalent; circuit model
摘要：This paper discusses a novel strategy of dynamic modeling of clarithromycin against Helicobacter pylori. A nonlinear fractional order equivalent circuit model is proposed to describe kill-time curves for different concentrations of antibiotics and different ages of bacteria. The efficiency of the time domain analysis method has been proved by plenty of tested data. All model parameters and variables, which come from external data, are closely related to the internal characteristics of antibiotics against bacterium. It provides a group of quantified indices of bactericidal mechanism in spite of knowledge of complex micro -scale mechanisms. A number of conjectures are presented to extend possible applications of this paper.