标题：How nanotechnology can enhance docetaxel therapy
作者：Zhang, Li; Zhang, Na
作者机构：[Zhang, Li; Zhang, Na] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China.
通讯作者地址：[Zhang, N]Shandong Univ, Sch Pharmaceut Sci, 44 Wen Hua Xi Rd, Jinan 250012, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF NANOMEDICINE
关键词：docetaxel; nanotechnology; nanoformulations; target delivery systems;; cancer therapy
摘要：Docetaxel has been recognized as one of the most efficient anticancer drugs over the past decade; however, its poor water solubility and systemic toxicity have greatly limited its clinical application. In recent decades, the emergence of nanotechnology has provided new drug delivery systems for docetaxel, which can improve its water solubility, minimize the side effects and increase the tumor-targeting distribution by passive or active targeting. This review focuses on the research progress in nanoformulations related to docetaxel delivery - such as polymer-based, lipid-based, and lipid-polymer hybrid nanocarriers, as well as inorganic nano-particles - addressing their structures, characteristics, preparation, physicochemical properties, methods by which drugs are loaded into them, and their in vitro and in vivo efficacies. Further, the targeted ligands used in the docetaxel nanoformulations, such as monoclonal antibodies, peptides, folic acid, transferrin, aptamers and hyaluronic acid, are described. The issues to overcome before docetaxel nanoformulations can be used in clinical and commercial applications are also discussed.