标题:Role of Inflammasome in Chronic Kidney Disease
作者:Li L.; Tang W.; Yi F.
作者机构:[Li, L] Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, 250012, China;[ Tang, W] Department of Pathogenic Bi 更多
通讯作者:Yi, F(fanyi@sdu.edu.cn)
通讯作者地址:[Yi, F] Department of Pharmacology, School of Basic Medical Sciences, Shandong UniversityChina;
来源:Advances in Experimental Medicine and Biology
出版年:2019
卷:1165
页码:407-421
DOI:10.1007/978-981-13-8871-2_19
关键词:Chronic kidney disease; Fibrosis; Inflammasome; Inflammation; Pattern recognition receptors
摘要:The inflammasome is a multiprotein complex assembled by intracytoplasmic pattern recognition receptors and is a key component of the innate immune system for host defense. Inflammasome recruits and activates the proinflammatory protease caspase-1 by recognizing pathogen-associated molecular patterns (PAMPs) or host-derived damage-associated molecular patterns (DAMPs). Activated caspase-1 cleaves the precursors of IL-1β and IL-18 to produce the corresponding mature cytokines. Several types of inflammasomes have been identified, such as NLRP3, NLRP1, IPAF (NLRC4) and AIM2. NLRP3 has recently been reported as a central pathogenic mechanism of chronic kidney disease (CKD). In this chapter, we briefly summarize the current knowledge about the roles of inflammasomes in the pathogenesis of CKD. A better understanding of the function of inflammasomes will provide unexpected opportunities to develop new therapies for kidney diseases by modulation of the innate immune system. © 2019, Springer Nature Singapore Pte Ltd.
收录类别:SCOPUS
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071281637&doi=10.1007%2f978-981-13-8871-2_19&partnerID=40&md5=05aa925540a9294d5257540e362c10e8
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