标题:Trajectories of childhood BMI and adult diabetes: the Bogalusa Heart Study
作者:Zhang, Tao; Xu, Jie; Li, Shengxu; Bazzano, Lydia A.; He, Jiang; Whelton, Paul K.; Chen, Wei
作者机构:[Zhang, Tao] Shandong Univ, Sch Publ Hlth, Dept Biostat, Jinan, Shandong, Peoples R China.; [Xu, Jie] Capital Med Univ, Beijing Tiantan Hosp, Dept N 更多
通讯作者:Chen, W
通讯作者地址:[Chen, W]Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, 1440 Canal St, New Orleans, LA 70112 USA.
来源:DIABETOLOGIA
出版年:2019
卷:62
期:1
页码:70-77
DOI:10.1007/s00125-018-4753-5
关键词:Body mass index; Childhood; Diabetes; Hyperglycaemia; Longitudinal study
摘要:Aims/hypothesisThe aim of this study was to characterise longitudinal profiles of BMI from childhood and to examine the impact of level-independent childhood BMI trajectories on adult type 2 diabetes.MethodsThe longitudinal cohort consisted of 2449 adults (1613 white and 836 black) who had their BMI measured between four and 15 times from childhood (4-19years) to adulthood (20-51years) and fasting glucose measured in adulthood. Model-estimated levels and linear slopes of BMI at childhood age points were calculated in 1-year intervals using growth-curve parameters and their first derivatives, respectively.ResultsBMI from childhood to adulthood fit cubic growth curves; linear and non-linear curve parameters differed significantly between race-sex groups. BMI showed race and sex differences from 15years onwards. Individuals with hyperglycaemia had higher long-term BMI levels than those who were normoglycaemic in race-sex groups. Linear and non-linear slope parameters of BMI differed consistently and significantly between adult hyperglycaemia groups. The OR of childhood BMI levels for ages 4-19years was 1.45-1.83 (p<0.001 for all) for adult hyperglycaemia after adjustment for confounders. Level-adjusted linear slopes of BMI at ages 10-19years showed significantly positive associations with adult hyperglycaemia (OR 1.17-1.50, p<0.01 for all). The associations of childhood BMI linear slopes with adult hyperglycaemia were not significant during the age period 5-9years. The trends in these associations were consistent across race-sex groups.Conclusions/interpretationThese observations indicate that childhood BMI trajectories have a significant impact on adult diabetes, independent of BMI levels. The adolescence age period is a crucial window for the development of diabetes in later life, which has implications for early-life prevention.Data availabilityAll data and materials are publicly available at the National Heart, Lung, and Blood Institute (NHLBI) Biologic Specimen and Data Repository and can be accessed at https://biolincc.nhlbi.nih.gov/studies/bhs.
收录类别:SCOPUS;SCIE
WOS核心被引频次:1
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055523336&doi=10.1007%2fs00125-018-4753-5&partnerID=40&md5=05dd5aefab7ae82e5560c1198b6bd057
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