标题：Bioactivity of micropatterned TiO2 nanotubes fabricated by micro-milling and anodic oxidation
作者：Wang, Guisen; Wan, Yi; Ren, Bing; Liu, Zhanqiang
作者机构：[Wang, Guisen; Wan, Yi; Ren, Bing; Liu, Zhanqiang] Shandong Univ, Sch Mech Engn, Key Lab High Efficiency & Clean Mfg, Jinan 250061, Shandong, Peoples 更多
通讯作者地址：[Wan, Y]Shandong Univ, Sch Mech Engn, Key Lab High Efficiency & Clean Mfg, Jinan 250061, Shandong, Peoples R China.
来源：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
关键词：Titanium; Micro/nanostructure; Micro-milling; Anodic oxidation;; Bioactivity
摘要：Although many methods have been proposed to fabricate a micro/nanostructure on titanium surface for enhanced cellular responses to implants, it has been challenging to construct an orderly micro/nanostructure. In this study, an ordered structure of micropatterned TiO2 nanotubes was produced on titanium surface by the combined use of micro-milling and anodic oxidation. The surface properties of different modified titanium samples were investigated by field emission scanning electron microscopy, laser scanning microscope, X-ray diffraction, and contact angle goniometer. The corrosion resistance of different samples was evaluated by an electrochemical workstation. A series of cell experiments were performed to evaluate the responses of osteoblasts to the modified titanium substrates. The results indicated that the surface roughness and hydrophilicity of micro/nanostructured titanium remarkably increased compared to the polished titanium. In addition, the corrosion resistance of micro/nanostructured titanium samples was also improved in comparison to the polished titanium samples. More importantly, the proliferation and differentiation of cells were significantly promoted on micro/nanostructure titanium substrates. This study provides a promising method to construct a regular micro-and nano-structure on titanium surface for cytocompatibility improvement.