标题：A rhodamine chromene-based turn-on fluorescence probe for selectively imaging Cu2+in living cell
作者：Liu, Wei-Yong ;Li, Hai-Ying ;Lv, Hong-Shui ;Zhao, Bao-Xiang ;Miao, Jun-Ying
作者机构：[Liu, Wei-Yong ;Lv, Hong-Shui ;Zhao, Bao-Xiang ] Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Ji 更多
来源：Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
摘要：We describe the development of a rhodamine chromene-based turn-on fluorescence probe to monitor the intracellular Cu2+level in living cells. The new fluorescent probe with a chlorine group in chromene moiety exhibits good membrane-permeable property than previous reported because the predicted lipophilicity of present probe 4 is stronger than that of methoxyl substituted probe in our previous work (CLogP of 4: 8.313, CLogP of methoxyl substituted probe: 7.706), and a fluorescence response toward Cu2+under physiological conditions with high sensitivity and selectivity, and facilitates naked-eye detection of Cu2+. The fluorescence intensity was remarkably increased upon the addition of Cu2+within 1 or 2 min, while the other sixteen metal ions caused no significant effect. © 2012 Elsevier B.V. All rights reserved.